OA08.01. Cholecystokinin antagonizes opioid function during electroacupuncture inhibitory effect on pressor reflex in rats
نویسندگان
چکیده
Purpose Acupuncture or electroacupuncture (EA) is increasingly being accepted as a viable therapy in the United States and may serve as an alternative treatment to drug therapy in patients with mild to moderate hypertension. We have demonstrated that EA acts through an opioid mechanism in the rostral ventrolateral medulla (rVLM) to inhibit sympathoexcitatory reflexes induced by gastric distention. Cholecystokinin octapeptide (CCK-8), a gastrointestinal peptide hormone, is present throughout the central nervous system and mediates pain and anxiety. CCK-8 interacts with CCK1 and CCK2 receptors. The present study investigated the hypothesis that CCK-8 in the rVLM limits the modulatory action of EA effect on sympathoexcitatory responses.
منابع مشابه
Nociceptin in rVLM mediates electroacupuncture inhibition of cardiovascular reflex excitatory response in rats.
Electroacupuncture (EA) at Neiguan-Jianshi acupoints through an opioid mechanism inhibits the cardiovascular pressor response induced by mechanical stimulation of the stomach. Because nociceptin also may regulate cardiovascular activity through its action in the brain stem, we hypothesized that this neuromodulator serves a role in the EA-related inhibitory effect. Blood pressure in ventilated m...
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